Tetratricopeptide repeat protein 23 (TTC23) (TTC23)

Tetratricopeptide repeat protein 23 (TTC23) is a protein-coding gene characterized by the presence of tetratricopeptide repeat (TPR) domains, which are structural motifs that facilitate protein-protein interactions and the assembly of multiprotein complexes [1][2]. Although its specific molecular function is not fully elucidated, TTC23 is hypothesized to participate in cellular signaling pathways and potentially the regulation of the cell cycle or ciliary function [1][3]. Significant interest in TTC23 arises from genome-wide association studies (GWAS) that have identified the TTC23 locus as a major determinant of renal function, specifically the estimated glomerular filtration rate (eGFR), and its association with serum urate levels and blood pressure [4][5]. Currently, there are no FDA-approved drugs or clinical-stage candidates that specifically target TTC23 mRNA or the TTC23 protein [6]. Consequently, while it is a gene of interest in the study of chronic kidney disease and metabolic disorders, it is not yet an established therapeutic target in clinical practice [6][7].

Other names

Tetratricopeptide repeat domain 23HCC-8TTC23

None currently established