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Target intelligence / Profile preview
Tetratricopeptide repeat protein 29 (TTC29)
- Target
- TTC29
- Molecular classification
- Other (Tetratricopeptide repeat [TPR] domain-containing protein), Axonemal protein
01
Overview
Tetratricopeptide repeat protein 29 (TTC29) is an axonemal protein containing tetratricopeptide repeats, which are protein-protein interaction motifs known for mediating the assembly of multiprotein complexes[1]. TTC29 is involved in the structure, organization, and movement of cilia, specifically in the regulation of flagellum assembly and motility in sperm. Its biological role is critical for normal sperm function, and mutations or defects in TTC29 have been associated with male infertility, primarily spermatogenic failure and sperm motility disorders[2][3][5][6]. TTC29 is not currently established as a drug target and has no documented pharmacological interactors or associated safety concerns.
- Other names
- Tetratricopeptide repeat domain 29Tetratricopeptide repeat protein 29TPR repeat protein 29NYD-SP14Protein TBPP2ATestis development protein NYD-SP14SPGF42TBPP2ATesticular secretory protein Li 62
02
Biological functions
Cilium movementCilium organizationRegulates sperm flagellum assembly and beatingSperm motility
03
Disease associations
Spermatogenic failure 42Non-syndromic male infertility due to sperm motility disorder
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