Tetratricopeptide repeat protein 7B (TTC7B)

Tetratricopeptide repeat protein 7B (TTC7B) is a scaffolding protein characterized by multiple tetratricopeptide repeat motifs that facilitate the assembly of multi-protein complexes. Its primary biological role is as a regulatory subunit of the plasma membrane phosphatidylinositol 4-kinase (PI4K) complex, which also includes the catalytic subunit PI4KA and the adapter protein FAM126. This complex is essential for the synthesis of phosphatidylinositol 4-phosphate (PI4P), a critical signaling lipid that regulates vesicle trafficking, lipid transport, and the recruitment of signaling proteins to the plasma membrane (UniProt Q86TV1; PubMed: 24790097). While TTC7B is a paralog of TTC7A, which is well-known for its role in multiple intestinal atresia and combined immunodeficiency (MIA-CID), TTC7B has been more closely linked to neurodevelopmental processes and the maintenance of membrane integrity in various tissues. In the context of drug development, TTC7B is considered a potential target for modulating the PI4K pathway, which is frequently dysregulated in cancers and exploited by certain viruses for replication. Current therapeutic strategies focus on disrupting the interaction between TTC7B and PI4KA to selectively inhibit lipid signaling in disease states, though no drugs targeting this specific protein have reached clinical use yet (PubMed: 27503894; PubMed: 25103138).

Other names

TTC7BTetratricopeptide repeat domain 7BFLJ38380

Modulation of the PI4KA-TTC7-FAM126 complex to regulate phosphatidylinositol 4-phosphate (PI4P) production