TFPI2 divergent transcript (TFPI2-DT)

TFPI2 divergent transcript (TFPI2-DT) is a long non-coding RNA identified at the human genome locus associated with the TFPI2 gene. Unlike the well-characterized TFPI2 protein, which is a secreted Kunitz-type serine protease inhibitor and has established roles in tumor suppression, extracellular matrix remodeling, and diseases like cancer and thrombosis[1][5], the TFPI2-DT transcript does not code for protein and its biological or pathological significance is currently unclear in the scientific literature. The entry "TFPI2-DT" can be mistaken for the TFPI2 protein and should be referenced carefully[3]. Summary of Key Issues: - The term "TFPI2 divergent transcript" refers to a non-coding RNA with limited to no functional characterization. - Most published research and clinical relevance pertains to the protein-coding gene TFPI2, not TFPI2-DT. - It is not an established drug target and should not be conflated with TFPI2 protein in structured drug target databases[3].

Other names

NR_134235.1

Not applicable; no known drugs or molecules with mechanism of action targeting TFPI2-DT.