TGFB2 antisense RNA 1 (TGFB2-AS1)

TGFB2 antisense RNA 1 (TGFB2-AS1) is a long non-coding RNA (lncRNA) located on chromosome 1, transcribed in the antisense direction relative to the TGFB2 gene. It is primarily induced by transforming growth factor β (TGF-β) signaling via canonical Smad and MAPK pathways. TGFB2-AS1 is nuclear-localized and modulates gene expression by associating with chromatin regulatory complexes such as Polycomb repressive complex 2 (PRC2) through its interaction with the EED subunit, leading to histone H3K27 trimethylation and repression of TGF-β target genes[1]. Functionally, TGFB2-AS1 acts as a negative regulator of TGF-β/Smad-mediated transcription, thus providing an auto-regulatory negative feedback mechanism that helps fine-tune TGF-β and BMP signal transduction. In cancers, especially triple-negative breast cancer (TNBC), higher levels of TGFB2-AS1 are associated with reduced tumorigenic and metastatic potential, in part by antagonizing TGF-β2 signaling and by limiting cancer stem cell (CSC)–like properties. While it regulates pathways critical in cancer progression and cellular differentiation, TGFB2-AS1 itself is not a conventional drug target such as a receptor, enzyme, or transporter but is a critical non-coding RNA regulator implicated in disease prognosis and cell fate determination[1][2][3][4].

Other names

TGFB2-AS1TGFB2 antisense RNA 1 (head to head)lncRNA TGFB2-AS1

Not applicable (no direct pharmacological targeting described)