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TGFB3 antisense RNA 1 (TGFB3-AS1)
- Target
- TGFB3-AS1
- Molecular classification
- Other (Long non-coding RNA, lncRNA)
01
Overview
TGFB3 antisense RNA 1 (TGFB3-AS1) is a long non-coding RNA transcribed antisense to the TGFB3 (transforming growth factor beta 3) gene. Unlike protein-coding therapeutic targets, it functions primarily through post-transcriptional regulation: TGFB3-AS1 regulates inflammatory response in macrophages by inhibiting the maturation of miR-144, a microRNA, and stabilizing Rap1a, a signaling protein. These actions promote Wnt signaling and inflammatory cytokine expression, particularly in contexts such as homocysteine-induced macrophage activation. Currently, there are no known drugs that directly target TGFB3-AS1, nor is it a recognized therapeutic target, but it is implicated in disease-related inflammatory processes[2].
- Other names
- ENST00000553732TGFB3-AS1
02
Mechanism of action
TGFB3-AS1 inhibits maturation of miR-144 by directly binding to its primary transcript (pri-miR-144) and interfering with Drosha and DGCR8-mediated processing[2] Stabilizes Rap1a protein via inhibition of ubiquitin-proteasome-mediated degradation, thereby augmenting Wnt signaling and promoting inflammatory gene expression in macrophages[2]
03
Biological functions
Regulation of mRNA and protein expressionModulation of microRNA (miRNA) processingInflammatory response in macrophages[2]
04
Disease associations
Inflammation (e.g., macrophage-driven inflammation)[2]Potential roles in cardiovascular and metabolic diseases due to macrophage activation (based on involvement in homocysteine-induced inflammation)[2]
05
Safety considerations
Not established as a therapeutic target. Manipulation of TGFB3-AS1 may broadly affect miRNA processing and inflammatory pathways, but specific safety issues are unknown[2]
06
Biomarkers
TGFB3-AS1 expression (potential marker for macrophage activation in inflammatory conditions)[2]Levels of mature miR-144, Rap1a, and Wnt pathway proteins as downstream biomarkers in specific cellular contexts[2]
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