THAP domain containing 12 pseudogene 5 (THAP12P5)

THAP domain containing 12 pseudogene 5 (THAP12P5) is classified as a human **pseudogene**, meaning it is a genomic DNA sequence similar to a known gene but typically non-functional due to mutations, deletions, or lack of regulatory elements necessary for expression[1]. It is named for its sequence similarity to the functional gene **THAP12**, which encodes a THAP domain—a protein motif involved in zinc-dependent, sequence-specific DNA binding and implicated in transcriptional regulation, apoptosis, and cell cycle control in its active, protein-coding relatives[2][3][4][5]. However, **THAP12P5** itself is not known to be transcribed or to produce a functional protein, and no data support a role in disease, drug targeting, or cell signaling pathways[1]. Context: - The **THAP** (Thanatos-associated protein) domain family has several functional members (e.g., THAP1, THAP12) encoding DNA-binding regulatory proteins, but THAP12P5 is not one of them[2][4]. - Functional THAP genes (such as THAP12) play roles in cell proliferation, DNA binding, protein dimerization, and regulation of interferon-induced kinase signaling[5]. - As with other pseudogenes, THAP12P5 may serve as a genomic marker, but there is no evidence supporting any functional or clinical relevance so far[1]. Summary: THAP12P5 is **not a receptor, enzyme, or other therapeutic target**; it is a pseudogene related by sequence identity to the THAP domain protein family, with no independent biological or disease role, and is not actionable in drug discovery or clinical diagnostics[1].

Other names

PRKRIRP5protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 5THAP12P5

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