THAP domain-containing protein 7 (THAP7)

THAP domain-containing protein 7 (THAP7) is a nuclear protein characterized by the presence of a highly conserved THAP domain, a zinc-coordinating DNA-binding fold found at its N-terminus[1][3][2]. THAP7 is primarily found associated with chromatin, where it binds to histone tails and functions as a transcriptional corepressor by recruiting HDAC3 and nuclear hormone receptor corepressors, thereby repressing gene expression[2][4][7]. It plays a role in chromatin organization and negative regulation of transcription mediated by RNA polymerase II[2][4][7]. Although its transcriptional repression function links THAP7 to basic cellular processes, direct disease roles and pharmacological targeting remain largely unexplored. THAP7 is one member of the larger THAP protein family, which is involved in diverse cellular processes including transcriptional repression and DNA binding, largely through interactions with specific DNA motifs mediated by its THAP domain[1][3][4].

Other names

THAP domain containing 7THAP7MGC10963THAP domain-containing protein 7

no drugs directly target THAP7, so mechanism of drug action is not established