Target intelligence / Profile preview

Thermolysin (TLN)

Target: TLN
Molecular classification: Enzyme, Metalloproteinase

Overview

Thermolysin is a thermostable neutral metalloproteinase enzyme produced by the Gram-positive bacterium *Bacillus thermoproteolyticus*. It catalyzes the hydrolysis of peptide bonds containing hydrophobic amino acids and can also catalyze peptide bond formation via reverse hydrolysis reactions. It is widely used in peptide and protein research due to its broad substrate specificity and thermostability.

Other names: Bacillus thermoproteolyticus neutral proteinaseThermoaseThermoase Y10Neutral proteinaseProtease from Bacillus thermoproteolyticus rokko

Mechanism of action

Catalyzes the hydrolysis of peptide bonds containing hydrophobic amino acids. Can also catalyze peptide bond formation via reverse hydrolysis reactions.

Biological functions

ProteolysisPeptide bond hydrolysisPeptide synthesis (reverse hydrolysis)

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