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Target intelligence / Profile preview
Thermosensitive Liposome (TSL)
- Target
- TSL
- Molecular classification
- Lipid vesicle, Nanocarrier
01
Overview
Thermosensitive liposomes (TSLs) are engineered nanocarriers designed to release their encapsulated therapeutic agents in response to mild hyperthermia (39–42°C). They enable spatially and temporally controlled drug delivery, particularly for targeting tumors. Upon heating, the lipid bilayer undergoes a phase transition, increasing membrane permeability and releasing the drug. Different formulations exist, including traditional TSLs, lysolipid-containing TSLs (e.g., ThermoDox®), and polymer-modified TSLs.
- Other names
- Heat-sensitive liposomeThermoDoxLysolipid-containing thermosensitive liposomeLTSLPolymer-modified thermosensitive liposomePTSLTraditional thermosensitive liposomesTTSL
02
Mechanism of action
Lipid bilayer phase transition increases membrane permeability, leading to drug release in response to mild hyperthermia.
03
Biological functions
Drug deliveryTargeted drug release
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target heating and tissue damageRequirement for uniform heat distribution within target tissueSystemic toxicity if liposomes are unstable
06
Interacting drugs
Doxorubicin
2 more in the full profile.
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