Thiamine-dependent enzyme system

The thiamine-dependent enzyme system refers to a group of enzymes that require thiamine (vitamin B1), specifically its active coenzyme form thiamine diphosphate (TDP, also known as thiamine pyrophosphate or TPP), for their catalytic activity. These enzymes are essential for central metabolic pathways in all living organisms, including carbohydrate metabolism, amino acid catabolism, and the pentose phosphate pathway. Major enzymes involved include pyruvate dehydrogenase complex, α-Ketoglutarate dehydrogenase complex, Branched-chain α-ketoacid dehydrogenase complex, and Transketolase. Deficiency leads to impaired energy metabolism and neurological disorders.

Other names

Thiamine pyrophosphate-dependent enzyme systemTPP-dependent enzyme systemThDP-dependent enzyme system

Stabilization of carbanion intermediates during decarboxylation reactions