Thiamine-phosphate synthase

**Thiamine-phosphate synthase** is an enzyme found in bacteria, yeast, and plants that catalyzes a key step in the biosynthesis of thiamine (vitamin B1). It mediates the condensation of 4-methyl-5-(β-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to produce thiamine monophosphate (TMP), the precursor of the active cofactor thiamine diphosphate (ThDP/TPP). The enzyme is encoded by the gene thiE in many prokaryotes[1][2][3][8][9]. It is crucial for cell viability in microorganisms that synthesize thiamine de novo, but this enzyme and its pathway are not present in humans, who obtain thiamine from dietary sources[1][9]. Thiamine-phosphate synthase has not been established as a drug target, but it may be considered in antimicrobial drug development against bacteria or fungi that rely on endogenous thiamine biosynthesis. **Caveats:** - No evidence suggests thiamine-phosphate synthase is a direct, validated pharmacological target in current clinical medicine (antibiotic, cancer therapy, etc.). - Its relevance is primarily in microbial metabolism and as a potential (but not established) antimicrobial target. - The enzyme does not have a standard human homolog; humans absorb thiamine from the diet instead of synthesizing it. **References:** - All data above grounded in documented enzyme databases and review articles[1][2][3][8][9].

Other names

Thiamine-phosphate pyrophosphorylaseThiamine-phosphate diphosphorylaseTMP pyrophosphorylaseTMP-PPaseTP synthasethiE (gene symbol)thiCywbK

Not applicable for known drugs, as there are currently no approved drugs or inhibitors with clinical significance reported for this enzyme