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Target intelligence / Profile preview
Thiamine pyrophosphokinase 1 (TPK1)
- Target
- TPK1
- Molecular classification
- Enzyme, Kinase
01
Overview
Thiamine pyrophosphokinase 1 (TPK1) is an enzyme that catalyzes the phosphorylation of thiamine (vitamin B1) to thiamine pyrophosphate (TPP), a crucial coenzyme involved in central metabolic pathways. TPK1 plays an essential role in cellular energy metabolism. Deficiency or dysfunction can lead to impaired cerebral thiamine metabolism, resulting in neurodegeneration and neurological disorders. Its regulation has implications for nutritional deficiencies and cancer biology due to its impact on redox homeostasis under metabolic stress conditions.
02
Mechanism of action
Phosphorylation of thiamine to thiamine pyrophosphate (TPP)
03
Biological functions
Thiamine phosphorylationThiamine pyrophosphate (TPP) biosynthesisGlucose metabolismEnergy productionRedox homeostasis
04
Disease associations
Neurodegenerative diseaseWernicke-Korsakoff syndromeCancer
05
Safety considerations
Thiamine deficiencyNeurological disorders associated with thiamine deficiency
06
Interacting drugs
Pyrithiamine
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