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Thiamine Transporter (THTR)
- Target
- THTR
- Molecular classification
- Solute Carrier Family (SLC), SLC19 subfamily, Major Facilitator Superfamily (MFS), Transporter
01
Overview
Thiamine transporters are membrane proteins responsible for the cellular uptake of thiamine (vitamin B1), an essential coenzyme required for energy metabolism in all cells. Humans and other mammals cannot synthesize thiamine de novo, so dietary uptake and efficient cellular import are critical. The main human thiamine transporters are SLC19A2 (thiamine transporter 1, hTHTR1) and SLC19A3 (thiamine transporter 2, hTHTR2).
- Other names
- hTHTR1hTHTR2SLC19A2SLC19A3
02
Mechanism of action
High-affinity proton-coupled antiport of thiamine.
03
Biological functions
Thiamine uptakeVitamin B1 transportEnergy metabolism
04
Disease associations
Thiamine-responsive megaloblastic anemia syndrome (TRMA)Biotin-thiamin-responsive basal ganglia diseaseNeurological disordersMetabolic disorders
05
Safety considerations
Drug-nutrient interactionsInhibition by medicationsThiamine deficiency
06
Interacting drugs
Fedratinib
5 more in the full profile.
07
Biomarkers
Thiamine levels
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