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Target intelligence / Profile preview
Thiamine transporter protein
- Molecular classification
- Transporter, Solute Carrier Family (SLC), SLC19 family
01
Overview
Thiamine transporters are membrane proteins, primarily SLC19A2 (hTHTR1) and SLC19A3 (hTHTR2), responsible for the cellular uptake of thiamine (vitamin B1). These transporters are crucial for normal cellular metabolism, especially in tissues with high metabolic demand. Loss-of-function mutations or drug-induced inhibition can lead to severe metabolic and neurological disorders.
- Other names
- Vitamin B1 transporterThiamine uptake protein
02
Mechanism of action
Inhibition of thiamine transport
03
Biological functions
Thiamine transportVitamin uptakeCellular metabolismNutrient transport
04
Disease associations
Thiamine-responsive megaloblastic anemia syndrome (TRMA)Biotin-thiamine-responsive basal ganglia diseaseMetabolic disordersNeurological disorders
05
Safety considerations
Drug-induced thiamine deficiencyNeurological complications from thiamine deficiencyMetabolic complications from thiamine deficiency
06
Interacting drugs
Fedratinib
3 more in the full profile.
07
Biomarkers
Thiamine levels in blood/cerebrospinal fluidSLC19A2/SLC19A3 mutations
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