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Thioesterase superfamily member 4 (THEM4)
- Target
- THEM4
- Molecular classification
- Enzyme, Thioesterase, Protein coding gene
01
Overview
Thioesterase superfamily member 4 (THEM4), also known as CTMP (carboxyl-terminal modulator protein), encodes an enzyme with acyl-CoA thioesterase activity that hydrolyzes medium- and long-chain fatty acyl-CoA thioesters (C14–C18), suggesting a role in mitochondrial fatty acid metabolism. THEM4 is best known for its regulatory function as a negative modulator of protein kinase B (AKT1/PKB) by inhibiting its phosphorylation at the C-terminal, thereby impacting signal transduction pathways involved in cell survival and apoptosis. The expression of THEM4 is commonly reduced in various cancers, including glioblastomas, and it has been implicated in apoptotic signaling and disease progression[1][2][4][6].
- Other names
- Acyl-coenzyme A thioesterase THEM4CTMP (Carboxyl-terminal modulator protein, also known as C-terminal modulator protein)Acyl-CoA thioesterase THEM4Carboxyl-terminal modulator proteinC-terminal modulator protein
02
Mechanism of action
Modulation of PKB/AKT1 phosphorylation status (for molecules that could target this protein)
03
Biological functions
Regulation of protein kinase B (AKT1/PKB) signalingNegative regulation of PKB/AKT1 phosphorylationMitochondrial fatty acid metabolismApoptosisRegulation of mitochondrial-mediated cell death
04
Disease associations
Cancer (downregulated in glioblastoma)Noonan syndrome-like disorder with loose anagen hair 1Wolf-Hirschhorn syndrome
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