Thioesterase superfamily member 6 (THEM6)

Thioesterase superfamily member 6 (THEM6) is an endoplasmic reticulum (ER) membrane-associated protein, distinct within the thioesterase superfamily by its transmembrane domain, that plays a key role in the regulation of ether lipid composition and ER membrane integrity[1]. THEM6 is critical for maintaining intracellular lipid homeostasis, supporting sterol biosynthesis, and enabling appropriate activation of ER stress responses (notably the unfolded protein response, UPR) during therapeutic stress such as androgen deprivation in prostate cancer[1]. High THEM6 expression is associated with poor outcomes and therapy resistance in several cancers, including prostate, bladder, and breast cancers, and acts as a prognostic marker and potential therapeutic target[1][2][3]. THEM6 modulates the tumor immune microenvironment, cell cycle, and survival, and its loss impairs cancer cell proliferation and increases sensitivity to cancer therapy[1][2][3]. The biological and therapeutic roles of THEM6 are active areas of research; to date, no targeted drugs are known, but its properties suggest strong interest in oncology and immuno-oncology advancement[1][2][3].

Other names

Protein THEM6C8orf55PSEC0098DSCD75Mesenchymal stem cell protein DSCD75UPF0670 protein C8orf55UPF0670 protein THEM6

Not established for drugs; potential mechanisms would include inhibition of THEM6 function, which could sensitize tumors to existing therapies and disrupt pro-oncogenic lipid metabolism