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Thiol-Containing Protein

Molecular classification: Protein

Overview

Thiol-containing proteins are a broad class of proteins characterized by the presence of thiol (-SH) groups, primarily contributed by cysteine residues. These thiol groups play essential roles in protein structure, function, and regulation through various chemical modifications and redox reactions. They contribute to protein folding and stability via disulfide bonds, act as redox switches, participate in catalysis, coordinate metal ions, and regulate cellular oxidative stress responses.

Biological functions

Protein foldingSignal transductionAntioxidant defenseEnzymatic catalysisRedox regulation

Disease associations

Neurodegenerative diseaseCancerOxidative stress-related diseases

Safety considerations

Disruption of redox balanceProtein misfolding/aggregation

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