Thiol-rich proteins

Thiol-rich proteins are a diverse group of proteins characterized by a high content of cysteine residues, which provide reactive sulfhydryl (-SH) groups essential for their biological functions (Source [1, 15]). This class includes critical regulatory proteins such as Kelch-like ECH-associated protein 1 (Keap1), metallothioneins, and enzymes like thioredoxin reductase, which collectively govern cellular redox balance and heavy metal detoxification (Source [1, 5, 15]). These proteins primarily function as molecular sensors for oxidative and electrophilic stress; for instance, Keap1 detects stress and subsequently regulates the Nrf2 transcription factor to induce cytoprotective}

Other names

Cysteine-rich proteinsSulfhydryl-rich proteinsThiol-containing proteins