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Thiol-Specific Antioxidant Protein (TSA)

Target: TSA
Molecular classification: Enzyme

Overview

Thiol-specific antioxidant proteins are a family of enzymes crucial for cellular defense against oxidative stress. They reduce hydroperoxides using thiol-containing electron donors, maintaining redox homeostasis and protecting cells from ROS damage. Their dysfunction is linked to oxidative-stress-related diseases.

Other names: Antioxidant ProteinAOPPeroxiredoxinPrx

Mechanism of action

Reduction of hydroperoxide substrates via thiol-based catalysis

Biological functions

Antioxidant defenseRedox signalingDetoxification

Disease associations

Cardiovascular diseaseAtherosclerosisInflammationCancerOxidative stress-related diseases

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