Thioredoxin domain-containing protein 12 (TXNDC12)

Thioredoxin domain-containing protein 12 (TXNDC12) is an enzyme of the thioredoxin superfamily localized in the endoplasmic reticulum, functioning primarily as a protein-disulfide isomerase[1][5]. It catalyzes the formation and rearrangement of disulfide bonds during protein folding, contributing to the proper maturation of secretory and membrane proteins, and plays a protective role against endoplasmic reticulum stress[1][5]. TXNDC12 is upregulated in multiple cancers, including hepatocellular carcinoma and glioma, where it promotes tumor metastasis and epithelial–mesenchymal transition (EMT) through activation and nuclear translocation of β-catenin and upregulation of ZEB1[1][3]. Its high expression correlates with poor clinical outcomes and increased tumor aggressiveness, supporting its potential as a therapeutic target and prognostic biomarker in cancer[1][3].

Other names

Thioredoxin domain-containing protein 12TLP19ER protein 18ERp18ER protein 19ERp19ERP16ERP18ERP19hAG-1AGR1PDIA16Endoplasmic reticulum resident protein 18Endoplasmic reticulum resident protein 19Thioredoxin-like protein p19hTLP19anterior gradient homolog 1AG1TXD12_HUMANHTLP19HAG-1