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Target intelligence / Profile preview
Thioredoxin domain-containing protein 16 (TXNDC16)
- Target
- TXNDC16
- Molecular classification
- Thioredoxin superfamily, Redox-regulating protein, Endoplasmic reticulum lumen protein
01
Overview
Thioredoxin domain-containing protein 16 (TXNDC16) is a member of the thioredoxin superfamily. It is localized to the endoplasmic reticulum lumen, where it contributes to redox homeostasis, electron transfer, and protein folding. TXNDC16/ERp90 is implicated in the delivery or recruitment of substrates to ERAD (endoplasmic reticulum-associated degradation) machinery through interaction with ERFAD. This protein is encoded by the TXNDC16 gene on chromosome 14. Although associated in some genetic or expression studies with diseases such as post-vaccinal encephalitis and meningioma, there is no evidence that it is a direct therapeutic target or a biomarker, nor are there known drugs targeting this molecule.
- Other names
- ERp90KIAA1344ERP90thioredoxin domain containing 16
02
Biological functions
Protein foldingRedox homeostasisElectron transferSubstrate recruitment/delivery to ERAD (endoplasmic reticulum-associated degradation) retrotranslocation machinery
03
Disease associations
Post-vaccinal encephalitisMeningiomaOther (no confirmed direct disease causality or widespread disease association, primarily from expression/correlation data)
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