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Target intelligence / Profile preview
Thioredoxin domain-containing protein 2 (TXNDC2)
- Target
- TXNDC2
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Thioredoxin domain-containing protein 2 (TXNDC2) is an enzyme of the thioredoxin family that participates in redox homeostasis and protein-disulfide reduction, primarily in the testis. It is specifically expressed in spermatids and is thought to play a regulatory role in sperm development, potentially supporting the assembly of the fibrous sheath in the sperm tail. It is not currently considered a direct therapeutic target and has not been linked to specific drug interactions or safety concerns[2][3][5][7][8].
- Other names
- Thioredoxin domain containing 2SPTRXSPTRX1Sptrx-1Spermatid-specific thioredoxin-1Sperm-specific thioredoxin 1Testicular tissue protein Li 215thioredoxin domain containing 2 (spermatozoa)
02
Biological functions
Redox homeostasisProtein-disulfide reductase activitySperm developmentRegulation of fibrous sheath assembly in spermSpermatogenesis
03
Disease associations
Other (No direct associations with common diseases such as cancer, inflammation, neurodegenerative or cardiovascular disease found in current databases)
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