Thioredoxin domain-containing protein 8 (TXNDC8)

**Thioredoxin domain-containing protein 8** (TXNDC8), also known as spermatid-specific thioredoxin 3 (SPTRX3), is a germ-line-restricted member of the thioredoxin family expressed exclusively in male germ cells, particularly during spermatogenesis[1][3][4][5]. It localizes mainly to the Golgi apparatus in spermatocytes and spermatids and is implicated in the post-translational modification of proteins required for acrosomal biogenesis, possibly by reducing disulfide bonds. TXNDC8 serves as a clinical biomarker of male infertility, with elevated levels in defective sperm correlating with lower fertility rates in assisted reproduction[1][5]. There is no evidence that it is a direct therapeutic target, receptor, or enzyme relevant to drug therapy. **Clarifications:** - The query refers to "novel transcript, antisense to TXNDC8" with abbreviation "ENSG00000302400." There is no recognized entry for "ENSG00000302400" in major gene databases. The canonical TXNDC8 gene is associated with "ENSG00000204193"[5]. - "Novel transcript, antisense to TXNDC8" may refer to an uncharacterized non-coding RNA or annotation artifact, not a standard protein-coding target. - TXNDC8 itself is not a classical drug target (not a receptor, channel, transporter, etc.), and there are no known drugs acting on TXNDC8. **Key Point:** The target described as "novel transcript, antisense to TXNDC8" does not correspond to a well-recognized, structured therapeutic target. Information provided is for TXNDC8, the actual protein-coding gene. If the intended inquiry is about the antisense transcript, more context or clarification would be required, as there is no structured data for it in authoritative databases.

Other names

SPTRX-3TRX6BA427L11.2SPTRX3