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Target intelligence / Profile preview
Thioredoxin Enzyme System (TRX)
- Target
- TRX
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
The thioredoxin enzyme system (TRX) is a central cellular antioxidant and redox regulatory system. It consists of thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH. This system plays a crucial role in maintaining the cellular redox environment, defending against oxidative stress, and regulating various biological processes through its disulfide reductase activity. Targeting the bacterial TRX systems is a potential strategy for developing new antibiotics.
- Other names
- Thioredoxin systemTrx systemThioredoxin reductase system
02
Mechanism of action
Inhibition of thioredoxin reductase by binding to key cysteine/selenocysteine residues, disrupting the electron transfer chain from NADPH to thioredoxin and subsequent reduction of target proteins.
03
Biological functions
Antioxidant defenseMaintenance of cellular redox stateDNA synthesis/repairRedox-sensitive signaling pathway regulationRegulation of metabolismRegulation of proliferationRegulation of differentiationRegulation of migrationRegulation of apoptosisModulation of immune responsesRegulation of cell death pathways
04
Disease associations
CancerInfectious disease
05
Safety considerations
Overexpression or dysregulation linked with cancer progression/resistance.Potential for off-target effects due to the broad role of the TRX system in cellular redox regulation.
06
Interacting drugs
Gold compounds
1 more in the full profile.
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