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Target intelligence / Profile preview
Thioredoxin Reductase 1 (TrxR1)
- Target
- TrxR1
- Molecular classification
- Enzyme, Selenoprotein, Reductase, Flavoprotein
01
Overview
Thioredoxin reductase 1 (TrxR1) is a cytosolic selenoenzyme and a key component of the thioredoxin system. It catalyzes the NADPH-dependent reduction of thioredoxin (Trx), maintaining Trx in its reduced, active form. This activity is central to cellular redox homeostasis and antioxidant defense mechanisms. TrxR1 plays roles both in cancer prevention (by protecting normal cells from oxidative damage) and potentially in cancer progression due to its involvement in cell growth and survival pathways. Therapeutically targeting TrxR1 can induce cell death.
- Other names
- TXNRD1TR1
02
Mechanism of action
Inhibition of TrxR1 leading to increased oxidative stress and cell death (e.g., ferroptosis).
03
Biological functions
Antioxidant defenseRedox regulationCell signalingDNA repairAngiogenesisCell proliferationTranscriptional regulationCell survival
04
Disease associations
CancerOxidative stress-related diseases
05
Safety considerations
Potential for promoting tumor growth if not carefully targetedOff-target effects due to broad substrate specificity
06
Interacting drugs
Motexafin gadolinium
1 more in the full profile.
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