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Target intelligence / Profile preview
Thioredoxin Reductase 2
- Molecular classification
- Enzyme, Reductase, Flavoprotein
01
Overview
Thioredoxin Reductase 2 (TXNRD2) is a mitochondrial enzyme that plays a central role in maintaining redox homeostasis within mitochondria. It is essential for scavenging reactive oxygen species (ROS) and protecting cells from oxidative stress. TXNRD2 catalyzes the NADPH-dependent reduction of thioredoxin 2 (Trx2), which acts as an electron donor to peroxiredoxins, detoxifying hydrogen peroxide and peroxynitrite. Deficiency of TXNRD2 has been linked to increased apoptosis and influences differentiation processes.
- Other names
- TrxR2TxnRd2
02
Mechanism of action
TXNRD2 catalyzes the NADPH-dependent reduction of thioredoxin 2 (Trx2), which in turn reduces other proteins via cysteine thiol-disulfide exchange reactions. The reduced Trx2 acts as an electron donor to peroxiredoxins, detoxifying hydrogen peroxide and peroxynitrite.
03
Biological functions
Redox homeostasisAntioxidant defenseROS scavengingElectron donor
04
Disease associations
Cardiovascular diseaseVascular dysfunctionApoptosisOxidative stress related diseasesChondrogenesis related disorders
05
Safety considerations
Disruption of nitric oxide signalingIncreased mitochondrial ROS production
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