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Thioredoxin Reductase 2 (microbial) (None)
- Target
- None
- Molecular classification
- Enzyme, Flavoprotein oxidoreductase
01
Overview
Thioredoxin reductase 2 (microbial) is an essential enzyme that maintains cellular redox homeostasis in bacteria by transferring electrons from NADPH via FAD to reduce thioredoxin—a process central to DNA synthesis/repair, antioxidant defense, and regulation of protein function through reversible oxidation-reduction reactions. Its unique structure among microbes makes it both fundamental biologically and attractive pharmacologically as an antimicrobial target due to differences from mammalian counterparts.
- Other names
- TrxR2 (microbial)Thioredoxin reductaseTrxR
02
Mechanism of action
Inhibition of thioredoxin reductase activity, leading to disruption of cellular redox balance and oxidative stress.
03
Biological functions
Redox homeostasisAntioxidant defenseDNA synthesis and repairRedox signaling
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects on mammalian thioredoxin reductases, although microbial TrxRs are structurally distinct.
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