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Target intelligence / Profile preview
Thioredoxin-related transmembrane protein 1 (TMX1)
- Target
- TMX1
- Molecular classification
- Enzyme, Oxidoreductase, Thioredoxin family protein, Transmembrane protein
01
Overview
Thioredoxin-related transmembrane protein 1 (TMX1) is a member of the protein disulfide isomerase (PDI) family characterized by the presence of a thioredoxin-like domain and localization to the endoplasmic reticulum (ER) membrane. TMX1 catalyzes the formation, reduction, and isomerization of disulfide bonds in newly synthesized proteins, playing a central role in maintaining ER redox homeostasis and proper protein folding. It is implicated in cellular stress response mechanisms and may have a role in diseases involving oxidative stress and protein misfolding, such as cancer and cardiovascular disease.
- Other names
- TMX1TXNDC1Disulfide isomeraseThioredoxin domain-containing protein 1
02
Mechanism of action
Modulation of redox state, catalysis of disulfide bond formation and rearrangement, regulation of protein folding in the endoplasmic reticulum
03
Biological functions
Protein disulfide isomerizationRegulation of endoplasmic reticulum redox stateProtein foldingCellular stress response
04
Disease associations
CancerCardiovascular diseaseOther (potential link to oxidative stress-related pathologies)
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