Target intelligence / Profile preview

Thiostrepton-induced protein A (TipA)

Target: TipA
Molecular classification: Transcription factor, MerR superfamily regulator

Overview

TipA is a bacterial transcriptional regulator of the MerR superfamily that confers resistance to thiopeptide antibiotics. Upon binding to antibiotics like thiostrepton, TipA undergoes a conformational change that allows it to bind to promoter DNA and activate transcription of genes involved in drug resistance, including its own gene. It functions as a sensor and response element for thiopeptide antibiotics in various bacteria, particularly Streptomyces species.

Mechanism of action

Drug-induced conformational change relieves autoinhibition, activating target promoters.

Biological functions

Multidrug resistance regulationTranscriptional regulationAntibiotic sensing

Disease associations

Antibiotic resistance

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Contribution to antibiotic resistance

Interacting drugs

Thiostrepton

2 more in the full profile.

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