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ENSG00000249843 refers to the "thiosulfate sulfurtransferase-like domain containing 1 pseudogene" which is annotated as a pseudogene. Pseudogenes are genomic DNA sequences similar to normal genes but are non-functional due to mutations or lack of necessary regulatory elements for protein expression. Thus, this locus does not encode a functional sulfurtransferase enzyme (such as TSTD1 or TST), nor does it participate in known biological processes, molecular functions, or disease pathways. It should not be confused with the functional TSTD1 gene, which encodes an enzyme implicated in sulfur metabolism and is found under a different Ensembl ID[5]. Key notes: - The "pseudogene" status means it does not encode a functional protein and is not considered a therapeutic target or drug interaction partner. - Information in references about thiosulfate sulfurtransferase-like domain containing 1 (TSTD1) applies only to the protein-coding gene, not the pseudogene[5]. Summary of correctness and relevance: - This entry is a pseudogene and not a bona fide therapeutic target. - Any biological or pharmacological information about TSTD1 (the protein) does not apply to this pseudogene. - The term "pseudogene" should always be included to clarify non-functionality. If you need structured target information for the functional protein (TSTD1), use the entry for "Thiosulfate sulfurtransferase-like domain-containing 1 (TSTD1, ENSG00000184916)" instead[5].
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