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THO complex subunit 5 (THOC5)
- Target
- THOC5
- Molecular classification
- Other (THO complex subunit), member of the mRNA transcription/export complex [TREX], RNA processing-associated protein
01
Overview
THO complex subunit 5 (THOC5) is an evolutionarily conserved protein that is a component of the THO subcomplex within the transcription/export (TREX) complex. It participates in coupling transcriptional elongation, mRNA 3′ end processing, and nuclear export of a selective subset of mRNAs, particularly those rapidly induced by extracellular signals such as growth factors and cytokines. THOC5 is critical for the export of immediate-early genes and is essential for stem cell survival and differentiation. Its depletion affects the processing and export of inducible transcripts but not the bulk of steady-state mRNAs. THOC5 is phosphorylated in response to various stimuli, including oncogenic events, and may play a role in cancer development. Genetic studies indicate that it is indispensable for normal stem cell function, and its loss leads to defects in cell differentiation and survival mechanisms[1][2][3][4][6].
- Other names
- THO complex subunit 5 homologTHOC5C22orf19KIAA0983FmipfSAP79Functional spliceosome-associated protein 79NF2/meningioma region protein pK1.3Placental protein 39.2hTREX90PP39.2PK1.3Fms-interacting protein
02
Biological functions
mRNA processingmRNA export from nucleus3′ end cleavage of mRNATranscription elongationRegulation of immediate-early gene responseMaintenance of stem cell pluripotency and survivalCell differentiation and proliferation
03
Disease associations
Cancer (THOC5 is phosphorylated by several oncogenic tyrosine kinases, possibly linked to development)Other (impaired stem cell maintenance or differentiation)
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