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Target intelligence / Profile preview
Thomsen-Friedenreich Antigen (TF Antigen)
- Target
- TF Antigen
- Molecular classification
- Carbohydrate, Glycan, Oncofetal Antigen, Tumor-Associated Carbohydrate Antigen
01
Overview
The Thomsen-Friedenreich (TF) antigen is a disaccharide carbohydrate structure (Galβ1-3GalNAcα1-Ser/Thr) that serves as the core 1 structure in O-linked glycosylation. It is normally masked in healthy adult tissues but becomes unmasked or overexpressed in many carcinomas, making it a pan-carcinoma marker and a potential target for immunotherapy. It is involved in tumor cell adhesion, tissue invasion, and metastasis.
- Other names
- T-antigenT-Crypt antigenTF-antigenCD176Gal-GalNAc
02
Mechanism of action
Antibody-based therapies targeting TF antigen
03
Biological functions
Cell adhesionTissue invasionMetastasisImmunogenicityO-linked glycosylation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects in tissues with low-level TF expressionRisk of autoimmunity (though minimized by sequestered presentation in normal tissues)
06
Biomarkers
Pan-carcinoma markerDiagnostic marker for cancerPrognostic marker for cancer
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