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Threonine--tRNA ligase (TARS)
- Target
- TARS
- Molecular classification
- Enzyme, Aminoacyl-tRNA synthetase class II, Threonine-tRNA ligase class IIa
01
Overview
Threonine--tRNA ligase (TARS) is an enzyme that catalyzes the attachment of the amino acid L-threonine to its corresponding tRNA(Thr). This process is essential for accurate translation of the genetic code during protein synthesis. It belongs to the class II family of aminoacyl-tRNA synthetases and displays high specificity for both its substrate (L-threonine) and its cognate tRNA. Some members have acquired additional roles such as RNA splicing regulation, transcriptional control, translational regulation, cell signaling pathways involvement, or even acting as repressors under certain conditions.
- Other names
- Threonyl-tRNA synthetaseThreonyl-transfer RNA synthetaseTARS
02
Mechanism of action
Inhibition of aminoacylation, leading to disruption of protein synthesis
03
Biological functions
Aminoacylation of tRNAProtein biosynthesisTranslationRegulation of RNA splicingTranscriptional controlTranslational regulationCell signaling
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