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Target intelligence / Profile preview
Thrombopoietin Receptor (MPL)
- Target
- MPL
- Molecular classification
- Receptor, Hematopoietic cytokine receptor
01
Overview
The thrombopoietin receptor, also known as MPL or CD110, is a cell surface protein primarily responsible for mediating the effects of thrombopoietin (TPO), the chief cytokine regulating platelet production and megakaryocyte development. It plays a critical role in hematopoiesis, particularly in maintaining hematopoietic stem cells and controlling platelet counts.
- Other names
- CD110Myeloproliferative leukemia protein
02
Mechanism of action
Thrombopoietin receptor agonists (TPO-RAs) mimic TPO action by activating the MPL receptor, stimulating increased platelet production through downstream signaling cascades involving JAK/STAT, MAPK, and PI3K-AKT pathways.
03
Biological functions
Signal transductionHematopoiesisMegakaryocyte proliferationMegakaryocyte maturationPlatelet productionHematopoietic stem cell maintenance
04
Disease associations
ThrombocytopeniaBone marrow failure syndromesEssential thrombocythemiaPrimary myelofibrosisMyeloproliferative disorders
05
Interacting drugs
Romiplostim
1 more in the full profile.
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