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Target intelligence / Profile preview
Thrombospondin 1 (TSP1)
- Target
- TSP1
- Molecular classification
- Extracellular matrix glycoprotein
01
Overview
Thrombospondin 1 (TSP1) is a multifunctional extracellular matrix glycoprotein involved in cell-to-cell and cell-to-matrix interactions, angiogenesis inhibition, regulation of inflammation, and modulation of tumor progression. It interacts with multiple receptors and ligands, influencing diverse processes including hemostasis, wound healing, tumor biology, metabolism, neurodevelopment, and inflammation.
- Other names
- THBS1
02
Biological functions
Cell adhesionCell-matrix interactionAngiogenesis inhibitionRegulation of inflammationPlatelet aggregationTGFβ activationImmune modulationWound healingTissue repair
03
Disease associations
CancerMetabolic diseaseFibrotic disordersInflammationNeurodevelopmental disorders
04
Safety considerations
Context-dependent effects on tumor progressionPotential for pro-inflammatory or anti-inflammatory effects depending on contextActivation of TGFβ pathways leading to fibrosis
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