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Target intelligence / Profile preview
Thrombospondin type-1 domain-containing protein 7A (THSD7A)
- Target
- THSD7A
- Molecular classification
- Other (extracellular matrix protein), Type I membrane protein, N-glycoprotein
01
Overview
Thrombospondin type-1 domain-containing protein 7A (THSD7A) is a large, N-glycosylated, type I membrane protein found mainly in endothelial cells, especially of the placenta and umbilical cord. It features 21 extracellular domains arranged in a pattern of TSP-1-like and F-spondin-like domains and may function as a heparan sulfate binding site. A soluble form is released via proteolytic cleavage, which promotes endothelial cell migration, filopodia formation, and tube formation during angiogenesis, primarily mediated by focal adhesion kinase (FAK) signaling and cytoskeletal rearrangement. Mutations in, or autoimmune responses to, THSD7A are implicated in idiopathic membranous nephropathy, with specific autoantibodies used as biomarkers for diagnosis.
- Other names
- Thrombospondin type-1 domain-containing protein 7ATHSD7AKIAA0960THS7Asoluble THSD7Athrombospondin type I domain containing 7A
02
Biological functions
Cytoskeletal organizationEndothelial cell migrationTube formation/angiogenesisActin cytoskeleton rearrangementFilopodia formationFocal adhesion assemblyHeparan sulfate binding
03
Disease associations
Autoimmune kidney disease (idiopathic membranous nephropathy)BronchiectasisOsteoporosis (association with low bone mineral density)
04
Safety considerations
Autoimmunity: THSD7A is a target of pathogenic autoantibodies in membranous nephropathyGenetic variations may contribute to osteoporosis
05
Biomarkers
Autoantibodies against THSD7A as marker for idiopathic membranous nephropathySoluble THSD7A levels for angiogenic activity
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