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Target intelligence / Profile preview
Thromboxane A2 Receptor (TP)
- Target
- TP
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor, Seven-transmembrane domain receptor
01
Overview
The thromboxane A2 receptor (TP) is a G protein-coupled receptor that mediates the actions of thromboxane A2 (TXA2), a potent eicosanoid involved in platelet aggregation, vasoconstriction, and various inflammatory responses. It is a key target for antithrombotic therapies.
- Other names
- TBXA2RThromboxane/prostaglandin H₂ receptorProstanoid TP receptor
02
Mechanism of action
Thromboxane A2 receptor antagonists block the binding of thromboxane A2 to the TP receptor, thereby inhibiting platelet aggregation, vasoconstriction, and other downstream effects.
03
Biological functions
Platelet aggregationVasoconstrictionInflammationSignal transductionCell migrationApoptosis
04
Disease associations
Cardiovascular diseaseThrombosisMyocardial infarctionStrokePeripheral artery diseasePulmonary hypertensionEmbolismRenal pathologiesProstate diseases
05
Safety considerations
Risk of bleedingPotential for off-target effects
06
Interacting drugs
Thromboxane A2 receptor antagonists
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