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Thromboxane A2 synthase (None)
- Target
- None
- Molecular classification
- Enzyme, Cytochrome P450 superfamily, Cytochrome P450 monooxygenase family, CYP5 subfamily
01
Overview
Thromboxane A2 synthase (TXAS), also known as CYP5A1, is a cytochrome P450 enzyme responsible for the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2). TXA2 is a potent inducer of platelet aggregation and vasoconstriction, playing a critical role in hemostasis and cardiovascular physiology. Overproduction or dysregulation of TXAS/TXA₂ is implicated in major cardiovascular diseases. Inhibitors of TXAS have been explored as antithrombotic agents.
- Other names
- TXASCYP5A1Thromboxane synthase
02
Mechanism of action
Aspirin irreversibly inhibits cyclooxygenase enzymes, reducing PGH₂ available for TXAS. Thromboxane synthase inhibitors directly inhibit the enzyme.
03
Biological functions
Platelet activation/aggregationVasoconstrictionHemostasis
04
Disease associations
Cardiovascular diseaseMyocardial infarctionStrokePeripheral artery diseaseEmbolismPulmonary dysfunctionThrombosisAtherosclerosis
05
Safety considerations
Potential for increased bleeding risk with TXAS inhibitorsAspirin resistanceImbalance in pro- and anti-thrombotic factors
06
Interacting drugs
Aspirin
2 more in the full profile.
07
Biomarkers
TXA2 levels12-HHT levelsMDA levels
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