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Target intelligence / Profile preview
Thromboxane synthetase (None)
- Target
- None
- Molecular classification
- Enzyme, Cytochrome P450 family, CYP5A1
01
Overview
Thromboxane synthetase (TXAS), also known as thromboxane-A synthase (CYP5A1), is an enzyme that catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2). TXA2 is a potent vasoconstrictor and inducer of platelet aggregation, playing a critical role in hemostasis and cardiovascular physiology.
- Other names
- Thromboxane-A synthaseTXASThromboxane-A synthase 1
02
Mechanism of action
Inhibition of thromboxane A2 production
03
Biological functions
VasoconstrictionPlatelet aggregationHemostasisBone remodelingRed blood cell production
04
Disease associations
AtherosclerosisMyocardial infarctionAsthmaGhosal hematodiaphyseal dysplasia
05
Safety considerations
Overproduction or dysregulation of thromboxane A synthase activity has been implicated in several major cardiovascular diseases
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