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THUMP domain 1 NAT10 acetyltransferase adaptor (THUMPD1)

Target: THUMPD1
Molecular classification: Adapter protein, RNA-binding protein, Involved in RNA modification pathways

Overview

THUMP domain 1 NAT10 acetyltransferase adaptor (THUMPD1) is a protein that binds tRNA and is essential for NAT10-dependent tRNA acetylation, specifically the formation of N4-acetylcytidine (ac4C), a conserved RNA modification in both tRNA and rRNA. THUMPD1 functions as an adaptor, enabling the NAT10 enzyme to acetylate specific cytidine residues, thereby influencing processes such as RNA stability, translation, and ribosome biogenesis. THUMPD1 is not recognized as a direct therapeutic target, but it is crucial for the functioning of NAT10, which has implications in cancer, aging, and inflammatory disorders

Other names: FLJ20274TAN1

Biological functions

Acts as a tRNA-binding adaptor for NAT10 to mediate tRNA acetylationInvolved in N4-acetylcytidine (ac4C) modification of RNAParticipates in rRNA processing and processing of capped intron-containing pre-mRNA

Disease associations

Associated (via genetic variation) with neurodevelopmental disorders and possibly ocular anomaliesIndirectly involved in processes linked to inflammation, apoptosis, and potentially tumorigenesis through NAT10-mediated pathways

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