THUMPD3 antisense RNA 1 (THUMPD3-AS1)

THUMPD3 antisense RNA 1 (THUMPD3-AS1, also known as SETD5-AS1) is a **long non-coding RNA (lncRNA)** located on chromosome 3 (3p25.3), transcribed antisense to the THUMPD3 and SETD5 loci[1][2]. It functions as an **enhancer RNA (eRNA)** and regulates gene expression, particularly in the context of cancer, where it has been shown to promote proliferation and migration of tumor cells such as those in hepatocellular carcinoma and ovarian cancer[2][3]. THUMPD3-AS1 can act as a molecular sponge (ceRNA), modulating cellular pathways like hypoxia and interacting with various molecular signals important in malignancy[6]. Although high expression correlates with poor prognosis in cancer, there is currently no evidence of approved or investigational drugs directly targeting THUMPD3-AS1 as a therapeutic intervention, and its main significance is as a biomarker and regulator of oncogenic pathways rather than as a classical drug target[3][6].

Other names

SETD5-AS1SETD5 antisense RNA 1

Not drug-targeted: Current data lack evidence for direct pharmacological targeting[3][6] Regulation of nearby and co-expressed genes by transcriptional modulation and RNA-network effects[3][6]