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Target intelligence / Profile preview
Thymic Stromal Lymphopoietin Receptor
- Molecular classification
- Receptor, Cytokine Receptor, Type I cytokine receptor family
01
Overview
The thymic stromal lymphopoietin receptor (TSLPR) is a heterodimeric cell surface receptor complex consisting of CRLF2 and IL-7Rα. It mediates the biological effects of thymic stromal lymphopoietin (TSLP), a cytokine that plays a key role in initiating and modulating type 2 immune responses and is involved in inflammation, allergy, and immune homeostasis.
- Other names
- TSLPRCytokine Receptor-Like Factor 2CRLF2
02
Mechanism of action
TSLPR forms a heterodimeric receptor complex with IL-7Rα that binds TSLP, activating the JAK/STAT signaling pathway.
03
Biological functions
Immune cell developmentDendritic cell polarizationTh cell differentiationImmune regulationSignal transductionCell proliferationCell differentiation
04
Disease associations
AllergyAsthmaAtopic dermatitisAutoimmunityCancerCardiovascular diseaseInflammation
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