Target intelligence / Profile preview

Thymidine (dThd)

Target: dThd
Molecular classification: Nucleoside, DNA Building Block

Overview

Thymidine is a nucleoside and one of the four building blocks of DNA. It is incorporated into DNA during replication and is commonly used as a marker for cell proliferation in research. While not a direct therapeutic target itself, enzymes involved in its metabolism are targets for anticancer and antiviral drugs.

Other names: DeoxythymidineThymidine nucleoside2'-Deoxythymidine

Mechanism of action

N/A - Thymidine itself is not a drug target, but a substrate for enzymes targeted by drugs.

Biological functions

DNA synthesisCell proliferationPrecursor for dTTP

Disease associations

Cancer (indirectly, through nucleotide metabolism)Viral infection (indirectly, through nucleotide metabolism)

Safety considerations

Radioactive thymidine can be cytotoxic at high concentrationsDisruption of thymidine metabolism can lead to replication stress and genomic instability

Interacting drugs

Thymidine kinase inhibitors (e.g., Acyclovir, Ganciclovir)

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