Target intelligence / Profile preview

Thymidine Kinase (None)

Target: None
Molecular classification: Enzyme, Kinase

Overview

Thymidine kinase (TK) is an enzyme crucial for DNA synthesis and cell division. It catalyzes the phosphorylation of thymidine to thymidine monophosphate (dTMP), a precursor for DNA polymerization. There are two main human isozymes: cytosolic TK1, which is cell cycle-dependent, and mitochondrial TK2, which functions independently of the cell cycle. Viral TKs are targets for antiviral therapies. Serum TK1 levels can serve as a proliferation marker in cancer.

Other names: TKTK1TK2

Mechanism of action

Inhibition of thymidine phosphorylation by competitive or non-competitive mechanisms.

Biological functions

DNA synthesisCell cycle regulationPyrimidine salvage pathwayNucleotide metabolism

Disease associations

CancerMitochondrial disordersViral infections

Safety considerations

Potential for off-target effects when targeting viral TKsDevelopment of resistance to antiviral drugs

Interacting drugs

Aciclovir

1 more in the full profile.

Biomarkers

Serum TK1 levels

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