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Thymidine Kinase 1 (TK1)

Target: TK1
Molecular classification: Enzyme, Kinase, Phosphotransferase

Overview

Thymidine kinase 1 (TK1) is a cytosolic enzyme crucial for DNA synthesis and cell proliferation. It catalyzes the phosphorylation of thymidine to thymidine monophosphate (dTMP), an essential building block for DNA replication. TK1 operates in the DNA salvage pathway, recycling thymidine from degraded DNA or external sources back into nucleotides usable for new DNA synthesis. Elevated serum or plasma levels indicate increased cell turnover—commonly seen in cancers.

Other names: TK-1Soluble thymidine kinase 1

Mechanism of action

Inhibition of viral thymidine kinase

Biological functions

DNA synthesisDNA salvage pathwayCell proliferationCell cycle regulation

Disease associations

Cancer

Interacting drugs

Aciclovir

Biomarkers

Elevated serum/plasma TK1 levels in cancer

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