Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Thymidine Kinase 2 (TK2)
- Target
- TK2
- Molecular classification
- Enzyme, Deoxyribonucleoside kinase
01
Overview
Thymidine kinase 2 (TK2) is a mitochondrial enzyme that catalyzes the phosphorylation of pyrimidine deoxynucleosides, specifically thymidine, deoxycytidine, and deoxyuridine, to their corresponding monophosphate forms. This is essential for maintaining adequate pools of deoxynucleotide triphosphates (dNTPs) required for mitochondrial DNA (mtDNA) replication and repair. Mutations in the TK2 gene cause thymidine kinase 2 deficiency, leading to a myopathic form of mitochondrial DNA depletion syndrome.
- Other names
- MTDPS2MTTKSCA31PEOB3thymidine kinase 2, mitochondrialTK2-EXT
02
Mechanism of action
Phosphorylates pyrimidine deoxynucleosides to their monophosphate forms, providing building blocks for mtDNA replication and repair.
03
Biological functions
Maintenance of mitochondrial DNASynthesis of mitochondrial DNAPhosphorylation of thymidinePhosphorylation of deoxycytidinePhosphorylation of deoxyuridinedNTP synthesis
04
Disease associations
Mitochondrial DNA depletion syndromeMyopathy
05
Safety considerations
Thymidine kinase 2 deficiency leads to mitochondrial DNA depletion syndrome.
Beyond the preview
Go deeper on Thymidine Kinase 2 (TK2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Thymidine Kinase 2 (TK2).