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Thymidine Phosphorylase (TP)
- Target
- TP
- Molecular classification
- Enzyme, Pentosyltransferase
01
Overview
Thymidine phosphorylase (TP), also known as TYMP, is an enzyme involved in nucleoside metabolism. It catalyzes the reversible phosphorolysis of thymidine to produce thymine and 2-deoxy-D-ribose-1-phosphate. This reaction is crucial for pyrimidine metabolism, regulation of nucleoside levels, angiogenesis, and maintenance of mitochondrial DNA. TP is overexpressed in various tumors where it contributes to angiogenesis, tumor growth, and metastasis. Deficiency in TYMP causes mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
- Other names
- TdRPasePD-ECGFPDECGFGliostatinTYMP
02
Mechanism of action
Catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxy-D-ribose-1-phosphate.
03
Biological functions
Pyrimidine salvage pathwayAngiogenesisMitochondrial DNA maintenanceRegulation of nucleoside levels
04
Disease associations
Cancer progressionMitochondrial neurogastrointestinal encephalomyopathy (MNGIE)
05
Safety considerations
TP inhibitors may disrupt normal pyrimidine metabolismOver-inhibition of angiogenesis could lead to ischemiaPotential for substrate inhibition by thymine
06
Biomarkers
TP overexpression as a predictor for fluoropyrimidine response
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