Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Thymidylate Synthase (None)
- Target
- None
- Molecular classification
- Enzyme
01
Overview
Thymidylate synthase (TS) is a highly conserved enzyme (EC 2.1.1.45) that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), using 5,10-methylenetetrahydrofolate. This reaction provides the only de novo pathway for dTMP synthesis, which is essential for DNA replication and repair. Overexpression of TS has been observed in various cancers and correlates with poor prognosis and resistance to chemotherapeutic agents. It also has autoregulatory function by interacting with its own mRNA.
02
Mechanism of action
Inhibition of thymidylate synthase leads to depletion of dTMP pools causing DNA damage
03
Biological functions
DNA synthesisDNA repairCell proliferationCell cycle regulationRNA binding
04
Disease associations
Cancer
05
Safety considerations
Drug resistance due to overexpression or mutationsToxicities associated with chemotherapeutic agents
06
Interacting drugs
5-Fluorouracil
1 more in the full profile.
07
Biomarkers
TS expression levels
Beyond the preview
Go deeper on Thymidylate Synthase (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Thymidylate Synthase (None).