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Target intelligence / Profile preview
Thymopoietin (TP)
- Target
- TP
- Molecular classification
- Thymic hormone, Polypeptide
01
Overview
Thymopoietin is a thymic hormone involved in T cell differentiation and immune regulation. It acts pleiotropically, modulating intracellular cyclic GMP levels in mature T cells and cyclic AMP in precursor T cells, and upregulating interleukin 2 or 22 mRNA expression. It can stimulate or inhibit immune responses depending on context, making it useful for immunodeficiency, autoimmune diseases, and cancer therapy support.
- Other names
- Thymopentin (TP5)
02
Mechanism of action
Paracrine signaling; cGMP/cAMP modulation; IL pathway upregulation; T cell differentiation; Immunonormalization
03
Biological functions
T cell differentiationImmune regulationNeuromuscular transmission modulationACTH and β-endorphin release stimulation
04
Disease associations
ImmunodeficiencyAutoimmune diseasesCancer therapy supportRheumatoid arthritisAIDSSARS
05
Interacting drugs
Thymopentin (TP5)
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